Inherited Rare, Deleterious Variants in ATM Increase Lung Adenocarcinoma Risk
نویسندگان
چکیده
منابع مشابه
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
BACKGROUND The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB...
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PURPOSE In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin's disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers. EXPERIMENTAL D...
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Metastatic tumors account for 1% of all oral malignancies. Metastasis to jaw bones is common, particularly in the mandible, rare in the oral soft tissues, and account for only 0.1% of oral malignancies. The majority of metastatic cases (70%) reported in the literature have primary tumors located in the lung, breast, kidney, and colon. Metastasis is a biological complex process that involves det...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2020
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2020.08.017